is a comprehensive liposomal B vitamin formula delivering all eight essential B vitamins in their most bioavailable and metabolically active forms, alongside a Proprietary Blend of Phosphatidylcholine, Milk Thistle Seed Extract, and Trimethylglycine (TMG), in Quicksilver Scientific's advanced nanoemulsified phospholipid delivery system, designed to support energy metabolism, neurological function, methylation, liver detoxification, immune function, mood stability, and cognitive performance through rapid sublingual and mucosal absorption that bypasses the digestive barriers that compromise traditional B vitamin supplement bioavailability.

B vitamins are the ultimate biochemical multitaskers. All eight work together in interconnected metabolic pathways that govern the conversion of food into cellular energy (ATP), the synthesis and regulation of neurotransmitters (serotonin, dopamine, GABA, norepinephrine), the methylation cycle and homocysteine metabolism, the integrity of the myelin sheath protecting nerve fibers, the production of red blood cells, DNA synthesis and repair, and the Phase I and Phase II liver detoxification reactions that process hormones, environmental toxins, and metabolic waste. Because the body cannot store most B vitamins, daily repletion is essential — and because age, low stomach acid, genetic variation (particularly MTHFR variants affecting folate and B12 processing), medications (including PPIs, metformin, and oral contraceptives), stress, and poor diet all compromise B vitamin absorption and utilization, standard capsule supplementation frequently fails to deliver adequate cellular concentrations.

This formula emphasizes three specific design decisions that distinguish it from conventional B complexes. First, the three B vitamins most commonly impaired by genetic variation and poor conversion are provided in their pre-activated forms: Riboflavin as Riboflavin-5-Phosphate (the active R5P coenzyme form), B12 as Methylcobalamin (the pre-methylated neurologically active form), and Folate as Calcium Folinate (a highly bioavailable folinic acid intermediate that does not require MTHFR conversion and does not risk over-methylation in sensitive individuals, unlike 5-MTHF). Second, Trimethylglycine (TMG) is included as a complementary methyl donor that supports the methylation cycle independently of the folate-B12 pathway.

Third, Milk Thistle Seed Extract is included to support the liver detoxification pathways that the B vitamins themselves power, creating a formula that addresses not just B vitamin status but the detoxification and methylation processes those vitamins enable.

Lemon Raspberry flavor. Vegan. Use within 6 months of opening. 50 servings per 1.7 fl oz (50 mL) bottle at two pumps daily.

Key Benefits:

• Supports healthy energy metabolism and sustained cellular ATP production via all eight B vitamins
• Supports healthy neurological function, nerve conduction, and myelin integrity
• Supports methylation, homocysteine metabolism, and DNA synthesis via active B12, Folate, and TMG
• Supports healthy mood stability, cognitive function, and emotional balance via neurotransmitter cofactor activity
• Supports liver detoxification pathways via B vitamins, TMG, and Milk Thistle
• Supports healthy immune function via B6, B12, and Folate immune cell activity
• Riboflavin-5-Phosphate (R5P) provides active B2 for MTHFR enzyme optimization and energy metabolism
• Methylcobalamin provides pre-methylated, neurologically active B12 without conversion requirements
• Calcium Folinate provides active folate without 5-MTHF over-methylation risk for sensitive individuals
• TMG provides independent methyl donor activity alongside the B12-folate methylation pathway
• Milk Thistle supports hepatic detoxification and liver protection alongside the B vitamin complex
• Liposomal nanoemulsified delivery begins absorbing in the mouth for rapid pre-gastric uptake
• Bypasses absorption limitations from low stomach acid, age, medications, and genetic variation
• Lemon Raspberry flavor, vegan, no refrigeration required

Thiamin (Vitamin B1, as Thiamine HCl) — 12 mg (1,000% DV) — The essential coenzyme for pyruvate decarboxylation, the gateway reaction that moves glucose-derived pyruvate into the Krebs cycle for ATP production. Thiamine deficiency is one of the most consequential nutritional deficiencies for neurological function, and even subclinical depletion impairs cellular energy metabolism and nerve conduction.

Riboflavin (Vitamin B2, as Riboflavin-5-Phosphate) — 3.6 mg (277% DV) — Provided as R5P, the active coenzyme form that requires no conversion by the intestinal mucosa. R5P is the direct form of riboflavin used in FAD and FMN enzyme systems for the electron transport chain, fatty acid oxidation, and the activation of B6 and folate. It is also the essential cofactor for MTHFR enzyme activity, and adequate riboflavin status directly supports the efficiency of the entire folate-B12 methylation cycle.

Niacin (Vitamin B3, as Niacin and Niacinamide) — 10 mg (63% DV) — Dual-form B3 providing both forms for the synthesis of NAD+ and NADP+, the coenzymes central to the electron transport chain, DNA repair, and the sirtuin longevity protein activation pathway.

Vitamin B6 (as Pyridoxine HCl) — 6.7 mg (394% DV) — A cofactor for over 100 enzymatic reactions including neurotransmitter synthesis (serotonin, dopamine, GABA), the transsulfuration pathway for homocysteine metabolism, amino acid catabolism, and immune cell production.

Folate (as Calcium Folinate) — 850 mcg DFE (213% DV) — Calcium folinate is the calcium salt of folinic acid (5-formyl-tetrahydrofolate), a metabolically active folate intermediate that is directly utilized in the methylation cycle without requiring MTHFR conversion. This form is highly bioavailable, stable in liposomal formulations, and avoids the over-methylation risk that some individuals experience with direct 5-MTHF supplementation. It provides the folate needed for homocysteine remethylation, DNA synthesis, and methylation cycle support without the sensitivity concerns of the fully methylated form.

Vitamin B12 (as Methylcobalamin) — 500 mcg (20,833% DV) — The pre-methylated, neurologically active form of B12 that directly participates in the methylation of homocysteine to methionine and in the synthesis of myelin sheath components. Methylcobalamin requires no conversion and is the preferred form for neurological applications and individuals with reduced ability to convert cyanocobalamin.

Biotin (Vitamin B7) — 500 mcg (1,667% DV) — A cofactor for carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid catabolism. Also supports healthy hair, skin, and nail integrity and healthy nervous system function.

Pantothenic Acid (Vitamin B5, as Calcium d-Pantothenate) — 22.5 mg (450% DV) — Essential for Coenzyme A synthesis, the central cofactor for fatty acid metabolism, the Krebs cycle, and steroid hormone production in the adrenal glands.

Phosphatidylcholine (from Highly Purified Phospholipids) — The primary liposomal delivery vehicle providing the unilamellar phospholipid vesicles that encapsulate and deliver the B vitamin complex for sublingual and mucosal absorption. Also contributes cell membrane phospholipid support alongside its delivery function.

Milk Thistle Seed Extract — Silymarin compounds from milk thistle support hepatic detoxification function, Phase I and Phase II liver enzyme activity, antioxidant defense in liver tissue, and healthy bile production. Included specifically because the B vitamins in this formula power the liver's methylation and detoxification pathways, making liver support a clinically logical complement.

Trimethylglycine (TMG, as Betaine) — An osmolyte and independent methyl donor that supports homocysteine remethylation through the BHMT enzyme pathway, providing a complementary methylation route alongside the folate-B12 dependent pathway. TMG enhances the methylation support of the formula and provides additional liver and cellular hydration support.

Other Ingredients: Water, Glycerin, Ethanol, Tocofersolan (water-soluble Vitamin E), EDTA (as preservative), Natural Citrus Oils, Natural Mixed Tocopherols, Natural Flavoring (Lemon Raspberry).

Store at room temperature out of direct sunlight. No refrigeration required. Use within 6 months of opening. Keep out of reach of children.

Take 2 pumps by mouth once daily. Hold in mouth for 30 to 90 seconds before swallowing. Repeat to desired dosage or as directed by your healthcare professional.

Take on an empty stomach at least 10 minutes before meals for optimal mucosal absorption.

If pregnant, breastfeeding, or planning to become pregnant, consult your physician before use. If you have a medical condition or take medications, consult your healthcare practitioner before use.