MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration.

Product information

CAS Number: 1382799-40-7

Molecular Weight: 268.28

Formula: C9H14F2N2O3S

Chemical Name: (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylimino)-hexahydro-1H-pyrano[3,2-d][1,3]thiazole-6,7-diol

Smiles: CCN=C1N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1

InChiKey: UDQTXCHQKHIQMH-KYGLGHNPSA-N

InChi: InChI=1S/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response.

Products are for research use only. Not for human use.