Bax (2B12) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3042-50, MB3042-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q07812

Host: Mouse

Reactivity: Human,Monkey

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Bax in COS7, Raji, CEM and HelaLysates using Bax antibody.

Bioworld Molecular Weight: Calculated MW: 21 kDa; Observed MW: 21 kDa

Specificity: IgG2a

Alternative Name: Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4

Immunogen: Purified recombinant human Bax protein fragments expressed in E.coli

Conjugate: Unconjugated

Modification: Unmodified