UTRO Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35962-50, RA35962-100

Citations, Manuals and MSDS Available upon request.

Background: utrophin (UTRN) Homo sapiens This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-300

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 7402

Protein MW (KDa): 377

SWISS: P46939

Source: Rabbit

Research Use Only