LYL1 Polyclonal Antibody

Catalogue Numbers: BS61016-50, BS61016-100

Sizes: 50µl, 100µl

Alternative Name: Protein lyl-1; Class A basic helix-loop-helix protein 18; bHLHa18; Lymphoblastic leukemia-derived sequence 1; LYL1; BHLHA18

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P12980

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor β chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2α proteins. Lyl-1 and E2α protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LYL1 polyclonal antibody detects endogenous levels LYL1 protein.

Bioworld Molecular Weight: ~ 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of LYL1 polyclonal antibody at 1:500
Line1:HEK293T whole cell lysate
Line2:H9C2 whole cell lysate
Line3:Raw264.7 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human LYL1.

Conjugate: Unconjugated

Modification: Unmodified