For many, the historical-critical method has released a host of threats to Christian faith and confession. In Pandora's Box Opened, however, Roy Harrisville argues that despite the evils brought upon biblical interpretation by the historical-critical method, there is still hope for it as a discipline.

Harrisville begins by describing the emergence and use of the historical-critical method. He then attends to the malaise that has come over the method, which he says still persists. Finally, Harrisville commends the historical-critical method, though shorn of its arrogance. He claims that the method and all its users comprise a "Pandora's Box" that, when opened, releases "a myriad other pains," but hope still remains.