KCNIP3 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-19200-60, E-AB-19200-120, E-AB-19200-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: KCNIP3

Target Synonym: 4933407H12Rik; A type potassium channel modulatory protein 3; A-type potassium channel modulatory protein 3; AI413860; Calsenilin; CSEN; CSEN; DRE antagonist modulator; DRE-antagonist modulator; DREAM; EF hand transcription factor; KCHIP 3; KChIP3; KCNIP 3; Kcnip3; Kv channel interacting protein 3; Kv channel-interacting protein 3; MGC18289; Potassium channel interacting protein 3; R74849

Research Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9Y2W7

Background: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3) is a Protein Coding gene. Diseases associated with KCNIP3 include Alzheimer Disease. Among its related pathways are Cardiac conduction and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include calcium ion binding and transcription corepressor activity. An important paralog of this gene is KCNIP4.

Concentration: 1.62 mg/mL

Immunogen: Fusion protein of human KCNIP3

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only