Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3].Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment[4]. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP.

Product information

CAS Number: 22144-77-0

Molecular Weight: 507.62

Formula: C30H37NO6

Synonym:

Zygosporin A

NSC 209835

Chemical Name: (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12R, 13E, 15R, 15aR)-3-Benzyl-6, 12-dihydroxy-4, 10, 12-trimethyl-5-methylene-1, 11-dioxo-2, 3, 3a, 4, 5, 6, 6a, 9, 10, 11, 12, 15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate

Smiles: C[C@@]1(O)C=C[C@@H](OC(C)=O)[C@]23[C@H]([C@H](CC4C=CC=CC=4)NC2=O)[C@H](C)C(=C)[C@@H](O)[C@@H]3C=CC[C@H](C)C1=O |t:3,33|

InChiKey: SDZRWUKZFQQKKV-IRESTULGSA-N

InChi: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14-/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (197.00 mM; Need ultrasonic and warming)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.
2. Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.
3. Ken-Ichi Wada, et al. Hippo pathway regulation by cell morphology and stress fibers. 2011 Sep;138(18):3907-14.

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