c-Abl Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA22606-50, RA22606-100 Citations, Manuals and MSDS Available upon request. Background: ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) Homo sapiens This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410) . Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1:50-300 Alternative Names: Tyrosine-protein kinase ABL1 (EC 2.7.10.2;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150) Applications: IHC-p; IF (paraffin section) Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 25 Protein MW (KDa): 125 (200kd BCR-ABL complex) SWISS: P00519 Source: Rabbit Research Use Only