PTAFR Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-16022-60, E-AB-16022-120, E-AB-16022-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: PTAFR

Target Synonym: OTTHUMP00000004041; OTTMUSP00000010350; PAF R; PAF receptor; PAF-R; PAFr; Platelet activating factor receptor; Platelet-activating factor receptor; PTAFR; PTAFR; RP23-470B20.1

Research Areas: Cancer, Cardiovascular, Immunology, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P25105

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Concentration: 0.5 mg/mL

Immunogen: Synthetic peptide of human PTAFR

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:25-1:100

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only