STAT5b Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30136-50, RA30136-100

Citations, Manuals and MSDS Available upon request.

Background: signal transducer and activator of transcription 5B (STAT5B) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:500-1:2000 IHC: 1:50-1:200

Alternative Names: Signal transducer and activator of transcription 5B

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 6777

Protein MW (KDa): 90

SWISS: P51692

Source: Rabbit

Research Use Only