NPPB is a blocker of the outwardly rectifying chloride channel (ORCC).

Product information

CAS Number: 107254-86-4

Molecular Weight: 300.31

Formula: C16H16N2O4

Chemical Name: 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid

Smiles: [O-][N+](=O)C1C=C(C(O)=O)C(=CC=1)NCCCC1C=CC=CC=1

InChiKey: WBSMIPAMAXNXFS-UHFFFAOYSA-N

InChi: InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 150 mg/mL (499.48 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

0.1 mM NPPB in the bath solution reduces channel open probability from 0.89±0.06 to 0.11±0.04 (n=5, P<0.01). Dose-dependent inhibition of chloride currents is observed with a 50% inhibitory concentration (IC50) of 125 μM NPPB. NPPB itself also shows cytotoxicity against glioma cells with a GI50 of approximately 500 μM.

Products are for research use only. Not for human use.