Bis(m-PEG4)-N-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2182601-79-0

Molecular Weight: 413.50

Formula: C18H39NO9

Chemical Name: N,N-bis(2,5,8,11-tetraoxatridecan-13-yl)hydroxylamine

Smiles: COCCOCCOCCOCCN(O)CCOCCOCCOCCOC

InChiKey: SHFFXGVDVNYUOA-UHFFFAOYSA-N

InChi: InChI=1S/C18H39NO9/c1-21-7-9-25-15-17-27-13-11-23-5-3-19(20)4-6-24-12-14-28-18-16-26-10-8-22-2/h20H,3-18H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.