ZNF839 Polyclonal Antibody

Catalogue Numbers: BS61488-50, BS61488-100

Sizes: 50µl, 100µl

Alternative Name: Zinc finger protein 839; Renal carcinoma antigen NY-REN-50; ZNF839

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: A8K0R7

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: ZNF839, also known as C14orf131, is an 811 amino acid protein that contains one C2H2-type zinc finger. The gene encoding ZNF839 localizes to chromosome 14 and, due to alternative splicing events, four ZNF839 isoforms are expressed. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder å1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ZNF839 polyclonal antibody detects endogenous levels of ZNF839 protein.

Bioworld Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of ZNF839 polyclonal antibody at 1:500 dilution
Lane 1: H9C2 whole cell lysate(40ug)
Lane 2: RAW264.7 whole cell lysat(40ug)
Lane 3: Hela whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 44-89 of Human ZNF839.

Conjugate: Unconjugated

Modification: Unmodified