Rb (phospho Ser612) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15424-50, ES15424-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

Alternate Name: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Rb (phospho Ser612)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5925

Human SWISS Prot NO: P06400

Subcellular Location: Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.

Research Use Only